Authors: Mahfoudh Mohammed Al Asali , Khaled abdulaziz Almohaimeed , AbdAllah Mohamed Sayedahmed , Ahmed Hassan Osman Fadl , Khaled Ba wazir , Ziadullah Ashour Bay , Abdelbagi Abdalla Elbashir

Abstract

Aim:To assess the rates of survival and local recurrence following curative therapy for rectal cancer (RC) provided by a specialized unit at “Care Medical Hospital- Riyadh, Saudi Arabia”, over the previous 10 years.

Methods and Population: The records at “Care Medical Hospital–Riyadh” of the patients who received a significant curative therapy for RC between 01 January 2015 and 31 December 2024 were retrospectively examined. Radical operation was carried out by a specialized surgeon. The data of the patients were retrieved.

Results: A total of 241 performed anterior resection. The ratio of male-to-female was 1.2:1 (134 male versus 107 female), with a median age at surgery of 57 years. 58% and 30% of subjects received total neoadjuvant therapy (TNT) and neoadjuvant radiation, respectively. Adjuvant chemotherapy was provided to 46% of the cases. The median follow-up was 63 months, and 96.3% achieved total resection with negative margins. The rate of local recurrence was 2%, whereas that of total recurrence was 17%. The rate of 5-year overall survival was 89.2% and that of the 5-year DFS was 80%. Positivity of lymph nodes and tumor invasion depth had a considerable effect on overall and DFS rates (P. value < 0.001, 0.008, versus 0.003, 0.032, respectively) based on multivariate analysis. The rate of clinical and radiological leak and stenosis was 2% and 1.7% respectively.

Conclusion: Curative therapy for RC at Care Medical Hospital Arrawabi in Saudi Arabia has a long-term outcome comparable to international results.

Keywords: Outcomes, curative resection, rectal cancer.